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STEMCELL Technologies Tamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

Marque:  STEMCELL Technologies 72666

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Code produit. 17160102

  • 2301.75€ / 10g

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Description

Description

  • Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
  • Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
  • Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
  • Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
  • Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
  • Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)
Spécification

Spécification

10540-29-1
10 g
≥95%
trans-Tamoxifen
C26H29NO
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