STEMCELL Technologies Tamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

Marque: STEMCELL Technologies 72666

Code produit. 17160102

Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!

Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.

Description

Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)

Spécification

Synonyme	trans-Tamoxifen
Formule moléculaire	C₂₆H₂₉NO

Suggestions de produits

Description