STEMCELL Technologies Tamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

Marque: STEMCELL Technologies 72664

Code produit. 17150102

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Description

Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)

Spécification

Synonyme	trans-Tamoxifen
Formule moléculaire	C₂₆H₂₉NO

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