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DiscoverX PathHunter™ CCR5 Activated GPCR Internalization U2OS Cell Line
The PathHunter™ CCR5 Activated GPCR Internalization U2OS Cell Line measures CCR5 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.
Marque: DiscoverX 93-0653C3
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Description
The PathHunter™ CCR5 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. CCL3/MIP-1α) based internalization of CCR5 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged CCR5. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting CCR5-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Spécification
| Receptor Internalization | |
| Cell Lines | |
| 2 Vials | |
| BC038398 |
| U2OS | |
| Recombinant Human MIP-1α (CCL3) | |
| CCR5 |
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Nom du produit
DiscoverX PathHunter™ CCR5 Activated GPCR Internalization U2OS Cell Line
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