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Tocris Bioscience™ LDC 000067
Potent and selective CDK9 inhibitor (IC50 = 44 nM at CDK9-cyclin T1)
Marque: Tocris Bioscience™ 6752/25
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Description
LDC 000067 is a potent and selective CDK9 inhibitor (IC50 = 44 nM at CDK9-cyclin T1). Inhibits other CDKs in the micromolar range (IC50 values are 2.4, 5.5, 9.2, >10 and >10 μM for CDK2-cyclin A, CDK1-cyclin B1, CDK4-cyclin D1, CDK6-cyclin D3 and CDK7-cyclin H-MAT1, respectively). Inhibits P-TEFb-dependent in vitro transcription. Induces apoptosis in vitro and in vivo in combination with BI 894999.Spécification
| 3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide | |
| 25 mg | |
| 370.43 |
| 1073485-20-7 | |
| C18H18N4O3S | |
| 98% |