STEMCELL Technologies FK506

Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

Marque: STEMCELL Technologies 74154

Informations supplémentaires : Poids : 0.05000kg

Code produit. 17190332

Expédition estimée: 20-08-2024
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Description

FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.) It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.)
Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.)
In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.)
Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.)

Spécification

Synonyme	Tacrolimus
Formule moléculaire	C₄₄H₆₉NO₁₂

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