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STEMCELL Technologies FK506
Calcineurin/NFAT pathway inhibitor; Binds FKBP-12
Marque: STEMCELL Technologies 74152
Informations supplémentaires : Poids : 0.05000kg
Description
- FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.) It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.)
- Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.)
- In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.)
- Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.)
Spécification
104987-11-3 | |
10 mg | |
≥99% |
Tacrolimus | |
C44H69NO12 |