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  8. WYE 687 dihydrochloride, Tocris Bioscience™

WYE 687 dihydrochloride, Tocris Bioscience™

Code produit. 30001505
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Quantité:
10 mg
50 mg
Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.
Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.

Description

Potent and selective mTOR inhibitor

Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-Kα (∽100-fold) and PI 3-Kγ (∽500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis.

Identifiants chimiques

CAS 1062161-90-3
Formule moléculaire C28H32N8O3
Poids moléculaire (g/mol) 528.617
Clé InChI VDOCQQKGPJENHJ-UHFFFAOYSA-N
Synonyme methyl n-4-4-morpholin-4-yl-1-1-pyridin-3-ylmethyl piperidin-4-yl pyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate, pyrazolo pyrimidine, 9, methyl 4-4-morpholino-1-1-pyridin-3-ylmethyl piperidin-4-yl-1h-pyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate, methyl 4-4-morpholin-4-yl-1-1-pyridin-3-yl methyl piperidin-4-yl-1h-pyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate, methyl 4-4-morpholin-4-yl-1-1-pyridin-3-ylmethyl piperidin-4-yl-1hpyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate
CID PubChem 25229450
Nom IUPAC methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate
SMILES COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6

Spécification

Nom chimique ou matériau WYE 687 dihydrochloride
Quantité 50 mg
Poids de la formule 601.53
Pourcentage de pureté >98%
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