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USP5 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marque: Invitrogen PA528243
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Description
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse brain. Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (81%), Rhesus Monkey (92%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in unanchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Spécification
| USP5 | |
| Polyclonal | |
| Unconjugated | |
| USP5 | |
| AA407472; deubiquitinating enzyme 5; EGK_03293; Isopeptidase T; Isot; ISOT-1; testicular tissue protein Li 218; ubiquitin carboxy terminal hydrolase T; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5; ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5; Ucht; Usp5 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 22225, 8078 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.81 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| P45974, P56399 | |
| USP5 | |
| Recombinant fragment corresponding to a region within amino acids 503 and 858 of Human USP5 | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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Nom du produit
USP5 Polyclonal Antibody, Invitrogen™ > 100 μL; Unconjugated
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