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Thiamet G, Tocris Bioscience™
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Quantité:
10 mg
Description
Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.
Spécification
Spécification
Nom chimique ou matériau | Thiamet G |
CAS | 1009816-48-1 |
Formule moléculaire | C9H16N2O4S |
Quantité | 10 mg |
Synonyme | thiamet g |
Clé InChI | PPAIMZHKIXDJRN-LQOSVEJXSA-N |
SMILES | CCNC1=NC2C(C(C(OC2S1)CO)O)O |
Nom IUPAC | (3aS,5R,6R,7S,7aS)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol |
Poids moléculaire (g/mol) | 248.297 |
CID PubChem | 122172999 |
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