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Invitrogen™ TET1 Monoclonal Antibody (GT1462)
Mouse Monoclonal Antibody
Marque: Invitrogen™ MA516312
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Description
Recommended positive controls: 293T, DDDDK-human TET1-transfected 293T, NT2D1, NT2D1 nuclear extract. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
Spécification
| TET1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative | |
| Q3URK3, Q8NFU7 | |
| TET1 | |
| Recombinant protein encompassing a sequence within the center region of human TET1. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG2b |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| GT1462 | |
| Unconjugated | |
| TET1 | |
| 2510010B09Rik; AA517754; bA119F7.1; BB001228; CXXC finger 6; CXXC zinc finger 6; CXXC6; CXXC-type zinc finger protein 6; D10Ertd17e; KIAA1676; LCX; leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; mKIAA1676; MLL-TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein; ten-eleven translocation 1 gene protein homolog; ten-eleven translocation-1; tet methylcytosine dioxygenase 1; tet oncogene 1; Tet1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456; TET1-MLL | |
| Mouse | |
| Protein G | |
| RUO | |
| 52463, 80312 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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