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SSR 69071, Tocris Bioscience™
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Quantité:
10 mg
Description
High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.
Spécification
Spécification
| Nom chimique ou matériau | SSR 69071 |
| CAS | 344930-95-6 |
| Formule moléculaire | C27H32N4O7S |
| Quantité | 10 mg |
| Synonyme | d0b3mv, dsstox_cid_27368, dsstox_rid_82301, dsstox_gsid_47368, 2-6-methoxy-4-1-methylethyl-1,1-dioxido-3-oxo-1,2-benzisothiazol-2 3h-yl methoxy-9-2-1-piperidinyl ethoxy-4h-pyrido 1,2-a pyrimidin-4-one, 2-6-methoxy-1,1-dioxido-3-oxo-4-propan-2-yl-1,2-benzothiazol-2 3h-yl methoxy-9-2-piperidin-1-yl ethoxy-4h-py... |
| Clé InChI | DRZXDZYWZSKFDL-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC(=CC2=C1C(=O)N(S2(=O)=O)COC3=CC(=O)N4C=CC=C(C4=N3)OCCN5CCCCC5)OC |
| Nom IUPAC | 6-methoxy-1,1-dioxo-2-[[4-oxo-9-(2-piperidin-1-ylethoxy)pyrido[1,2-a]pyrimidin-2-yl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one |
| Poids moléculaire (g/mol) | 556.634 |
| CID PubChem | 9872438 |
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