SETDB1 Monoclonal Antibody (5H6A12), Invitrogen™

Description

MA5-15722 targets SETDB1 in indirect ELISA, IF and WB applications and shows reactivity with Human, mouse, and Non-human primate samples. The MA5-15722 immunogen is purified recombinant fragment of human SETDB1 expressed in E. Coli. MA5-15722 detects SETDB1 which has a predicted molecular weight of approximately 180kDa.

This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.