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Invitrogen™ SARS-CoV-2 Spike Protein (RBD) Recombinant Protein
Recombinant Protein
Marque: Invitrogen™ RP88317
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Description
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells.
Spécification
| ELISA | |
| PBS with 0.01% mannitol, 0.01% Tween 80, 5-8% trehalose and no preservative; pH 7.4 | |
| SDS-PAGE | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| <1.0 EU/ μg | |
| Protein | |
| Unconjugated | |
| SARS-CoV-2 spike RBD, amino acids Arg319-Phe541 (Accession # YP_009724390.1) | |
| HEK293 cells |
| Lyophilized | |
| 25.1 kDa | |
| 100 μg | |
| RUO | |
| Coronavirus; COVID; Covid 19; COVID19; COVID-19; SARS; SARS Coronavirus; SARS CoV; SARS CoV2; SARS CoV-2; SARS Spike Protein; SARS-CoV2; SARS-CoV-2 | |
| Virus | |
| Recombinant | |
| Measured by its binding ability in a functional ELISA. Immobilized S3-2019-nCov-RBD (at 2 μg/mL (100 μL/well) can bind ACE2 Protein, Human, Recombinant (mFc Tag) , the EC50 of ACE2 Protein, Human, Recombinant (mFc Tag) is 20-80 ng/mL) | |
| >90% as determined by SDS-PAGE. |