Invitrogen™ Rat Synaptophysin (aa 253-272) Synthetic Peptide

Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96. PEP-279 is a 20 amino acid synthetic peptide whose sequence corresponds to residues 253-272 of rat Synaptophysin. The sequence of this peptide is (amino to carboxy terminus): G (253)-P-G-G-Y-G-P-Q-D-S-Y-G-P-Q-G-G-Y-Q-P-D (272).This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, Synaptophysin, catalog &Num; PA1-1043. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 mL of distilled water.