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Picropodophyllotoxin, Tocris Bioscience™
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Quantité:
10 mg
Description
Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ∽ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.
Spécification
| Nom chimique ou matériau | Picropodophyllotoxin |
| CAS | 477-47-4 |
| Formule moléculaire | C22H22O8 |
| Numéro MDL | MFCD01742647 |
| Quantité | 10 mg |
| Synonyme | picropodophyllin, picropodophyllotoxin, igf-1r inhibitor, ppp, unii-0f35aoi227, axl1717 picropodophyllotoxin, picropodophyllin ppp, insulin-like growth factor-1 receptor inhibitor, furo 3',4':6,7 naphtho 2,3-d-1,3-dioxol-6 5ah-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-3,4,5-trimethoxyphenyl-, 5r-5-alpha,5a-alpha,8a-alpha,9-alpha, 5r,5ar,8as,9r-5-hydroxy-9-3,4,5-trimethoxyphenyl-5a,6,8a,9-tetrahydro-5h-2 benzofuro 5,6-f 1,3 benzodioxol-8-one, spectrum_001636 |
| Clé InChI | YJGVMLPVUAXIQN-HAEOHBJNSA-N |
| SMILES | COC1=CC(=CC(OC)=C1OC)[C@H]1[C@H]2[C@H](COC2=O)[C@@H](O)C2=CC3=C(OCO3)C=C12 |
| Nom IUPAC | (10R,11S,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one |
| Poids moléculaire (g/mol) | 414.41 |
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