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Phospho-EGFR (Tyr1101) Monoclonal Antibody (M199), Invitrogen™
Mouse Monoclonal Antibody
Marque: Invitrogen MA547640
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Description
This antibody antibody detects a 180 kDa* protein on SDS-PAGE immunoblots of human A431 cells treated with EGF, and does not detect this band in control cells.
EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Spécification
| Phospho-EGFR (Tyr1101) | |
| Monoclonal | |
| Lot-Specific | |
| PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide | |
| P00533, Q01279 | |
| EGFR | |
| Clone (M199) was generated from a phospho-EGFR (Tyr1101) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr1101 of human EGFR (ErbB-1). This human EGFR sequence has high homology to rat and mouse EGFR and is not conserved in other ErbB family members. This site is Tyr1125 in the P00533-1 version of human EGFR. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Liquid |
| Immunocytochemistry, Western Blot | |
| M199 | |
| Unconjugated | |
| EGFR | |
| 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2 | |
| Mouse | |
| Protein A | |
| RUO | |
| 13649, 1956, 24329 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| IgG1 |