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Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), FITC, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
194.00€ - 486.00€
Spécification
Antigène | Phospho-CREB (Ser133) |
---|---|
Clone | CREBS133-4D11 |
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugué | FITC |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
---|---|---|---|---|---|---|---|---|---|
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
17196858
|
Thermo Scientific
MA537273 |
10 Tests |
194.00€
10 pièces |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
17176578
|
Thermo Scientific
MA536991 |
100 Tests |
486.00€
100 pièces |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
Description
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.Spécification
Phospho-CREB (Ser133) | |
Flow Cytometry | |
FITC | |
Rabbit | |
Human, Mouse | |
P16220, Q01147 | |
12912, 1385 | |
A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB. | |
Primary | |
4° C, store in dark | |
CREB1 |
CREBS133-4D11 | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.20% BSA and 0.09% sodium azide | |
2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein | |
CREB1 | |
IgG κ | |
Protein A/G | |
Antibody |
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