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MRE11 Monoclonal Antibody (12D7), Invitrogen™
Mouse Monoclonal Antibody
Marque: Invitrogen MA123253
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Description
Recommended positive controls: HeLa, Jurkat, Raji, NCI-H929, 293T, human Mre11-transfected 293T, PC-12.
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
Spécification
| MRE11 | |
| Monoclonal | |
| 0.45 mg/mL | |
| PBS with no preservative | |
| P49959, Q61216 | |
| Mre11, Mre11a | |
| Amino acids 182-582 of Mre11 expressed in E. coli. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| ELISA, Functional Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Proximity Ligation Assay, Western Blot | |
| 12D7 | |
| Unconjugated | |
| Mre11 | |
| ATLD; AT-like disease; DNA recombination and repair protein; double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; Meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; meiotic recombination 11 homolog A (S. cerevisiae); mmMRE11A; MRE11; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); MRE11 meiotic recombination 11-like protein A; MRE11A; MRE11B; MRX complex nuclease subunit; NGS1; RAD58; XRS4; YM9959.06C; YMR224C | |
| Mouse | |
| Protein G | |
| RUO | |
| 17535, 4361 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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