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Invitrogen™ Lamin A/C Monoclonal Antibody (3A6-4C11), eBioscience™
Mouse Monoclonal Antibody
Marque: Invitrogen™ 14-9847-82
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Description
Description: This 3A6-4C11 monoclonal antibody recognizes human and mouse Lamin A and Lamin C - two splice variants of the LMNA gene. The 3A6-4C11 antibody has been also reported to cross-react with rat Lamin A/C. Applications Reported: This 3A6-4C11 antibody has been reported for use in western blotting and immunocytochemistry. Applications Tested: This 3A6-4C11 antibody has been tested by western blotting of human and mouse cell line lysates. This may be used at 0.5 μg/mL.
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
Spécification
| Lamin A/C | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P02545, P48678 | |
| LMNA | |
| Recombinant fragment of human Lamin A. | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG2a κ |
| Western Blot, Immunocytochemistry | |
| 3A6-4C11 | |
| Unconjugated | |
| LMNA | |
| 70 kDa lamin; cb948; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; I79_009616; IDC; lamin; lamin A; lamin A/C; lamin A/C L homeolog; lamin A/C-like 1; Lamin A+C mutant; Lamin AC; lamin a-c; lamin C; lamin C2; lamin-A; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; lmna; LMNA protein; lmna.L; lmna-A; LMNC; LMNL1; mutant 453W; Mutant lamin A/C; nuclear intermediate filament protein; nuclear lamin A; prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product; wu:fk66d12; XELAEV_18040808mg | |
| Mouse | |
| Affinity chromatography | |
| RUO | |
| 16905, 4000 | |
| 4°C, do not freeze | |
| Liquid |
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