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Lamin A/C Monoclonal Antibody (3A6-4C11), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marque: Invitrogen 14-9847-82
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Description
Description: This 3A6-4C11 monoclonal antibody recognizes human and mouse Lamin A and Lamin C – two splice variants of the LMNA gene. The 3A6-4C11 antibody has been also reported to cross-react with rat Lamin A/C. Applications Reported: This 3A6-4C11 antibody has been reported for use in western blotting and immunocytochemistry. Applications Tested: This 3A6-4C11 antibody has been tested by western blotting of human and mouse cell line lysates. This may be used at 0.5 μg/mL.
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
Spécification
| Lamin A/C | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide, pH 7.2 | |
| P02545, P48678 | |
| LMNA | |
| Recombinant fragment of human Lamin A | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG2a κ |
| Immunocytochemistry, Western Blot | |
| 3A6-4C11 | |
| Unconjugated | |
| LMNA | |
| 70 kDa lamin, cb948, CDCD1, CDDC, CMD1A, CMT2B1, Dhe, EMD2, FPL, FPLD, FPLD2, HGPS, I79_009616, IDC, lamin, lamin A, lamin A/C, lamin A/C L homeolog, lamin A/C-like 1, Lamin A+C mutant, Lamin AC, lamin a-c, lamin C, lamin C2, lamin-A, Lamin-A/C, LDP1, LFP, LGMD1B, LMN1, lmna, LMNA protein, lmna.L, lmna-A, LMNC, LMNL1, mutant 453W, Mutant lamin A/C, nuclear intermediate filament protein, nuclear lamin A, prelamin-A/C, PRO1, progerin mutant, Renal carcinoma antigen NY-REN-32, RP11-54H19.1, unnamed protein product, wu:fk66d12, XELAEV_18040808mg | |
| Mouse | |
| Affinity chromatography | |
| RUO | |
| 16905, 4000 | |
| 4° C, do not freeze | |
| Liquid |