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Chloroquine diphosphate, Tocris Bioscience™
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Quantité:
50 mg
Description
Chloroquine diphosphate is an antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977). Blocks receptor-mediated endocytosis of mannose-glycoconjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC50 = 1.13 μM). Chloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro, as well as enhancing non-viral gene transfection in breast cancer cells. Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
Spécification
Spécification
| Nom chimique ou matériau | Chloroquine diphosphate |
| CAS | 50-63-5 |
| Formule moléculaire | C18H32ClN3O8P2 |
| Numéro MDL | MFCD00069852 |
| Quantité | 50 mg |
| Synonyme | chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine |
| Clé InChI | QKICWELGRMTQCR-UHFFFAOYNA-N |
| SMILES | OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1 |
| Nom IUPAC | 7-chloro-N-[5-(diethylamino)pentan-2-yl]quinolin-4-amine; bis(phosphoric acid) |
| Poids moléculaire (g/mol) | 515.86 |
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