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CD1d Monoclonal Antibody (51.1), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marque: Affymetrix eBioscience 14-0016-95
Description
The MAb 51.1 reacts with human CD1d, a member of the CD1 family with similarity to the non-polymorphic MHC Class I-like molecules. CD1d is a highly conserved single transmembrane receptor of the Immunoglobulin Superfamily. CD1d can associate with beta-microglobulin another feature showing similarity to MHC class I molecules, but can also exist as a nonglycosylated protein not in association with beta microglobulin. This suggests different control mechanisms for presenting glycolipid containing molecules to CD1d reactive NKT cells. Expression of CD1d is found on B cells of the periphery, in resting monocytes and cortical thymocytes. On intestinal epithelial cells (IEC) expression is polarized. Expression can also be found at low levels intracellularly in hepatocytes. In HCV (hepatitis C virus) livers, CD1d is highly expressed compared to normal controls. The 51.1 MAb has been shown to have functional activity; blocking the interaction of CD1d transfected cells with NKT cells.
CD1d Monoclonal antibody specifically detects CD1d in Human samples. It is validated for Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
Spécification
| CD1d | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P15813 | |
| Mouse | |
| 10 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b κ |
| Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation | |
| 51.1 | |
| Unconjugated | |
| CD1D | |
| AI747460; Antigen-presenting glycoprotein CD1d; antigen-presenting glycoprotein CD1d1; Cd1; Cd1.1; Cd1a; Cd1d; CD1D antigen; CD1D antigen, d polypeptide; CD1d molecule; CD1d.1; Cd1d1; CD1d1 antigen; CD1d1 molecule; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; Ly-38; R3; R3G1; T-cell surface glycoprotein CD1d; T-cell surface glycoprotein CD1d1; thymocyte antigen CD1D | |
| Affinity chromatography | |
| RUO | |
| 912 | |
| 4° C | |
| Liquid |
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