Invitrogen™ Bovine Factor V Native Protein

Description

Factor V (bovine) Native Protein, RP-43127, from Invitrogen.

Coagulation factor V (or Proaccelerin) is an essential factor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The active factor V is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in the Factor V gene can result various diseases including Factor V deficiency, thrombophilia due to activated protein C resistance, Budd-Chiari syndrome, Ischemic stroke, and recurrent pregnancy loss. RP-43127 contains native bovine Factor V protein. RP-43127 may be used as a positive control in many immunological assays. The RP-43127 protein molecular weight is ∽330 kDa.