missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Produits chimiques
  4. Composés organiques
  5. Benzénoïdes
  6. Benzène et dérivés substitués
  7. Toluamides
  8. AP 24534, Tocris Bioscience™

AP 24534, Tocris Bioscience™

Code produit. 18075312
Click to view available options
Quantité:
10 mg
Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.
Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.

Description

Potent multi-kinase and pan-Bcr-Abl inhibitor

Potent multi-kinase and pan-Bcr-Abl inhibitor. Displays potent activity against cell lines expressing native Bcr-Abl or Bcr-AblT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other Abl kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active. Identified as targeting human host proteins that interact with SARS-CoV-2.

Identifiants chimiques

CAS 943319-70-8
Formule moléculaire C29H27F3N6O
Poids moléculaire (g/mol) 532.571
Clé InChI PHXJVRSECIGDHY-UHFFFAOYSA-N
Synonyme ponatinib, ponatinib ap24534, iclusig, 3-imidazo 1,2-b pyridazin-3-ylethynyl-4-methyl-n-4-4-methylpiperazin-1-yl methyl-3-trifluoromethyl phenyl benzamide, ap24534 ponatinib, iclusig tn, 3-2-imidazo 1,2-b pyridazin-3-yl ethynyl-4-methyl-n-4-4-methylpiperazin-1-yl methyl-3-trifluoromethyl phenyl benzamide, benzamide, 3-2-imidazo 1,2-b pyridazin-3-ylethynyl-4-methyl-n-4-4-methyl-1-piperazinyl methyl-3-trifluoromethyl phenyl, ponatinib usan:inn
CID PubChem 24826799
ChEBI CHEBI:78543
Nom IUPAC 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

Spécification

Nom chimique ou matériau AP 24534
Quantité 10 mg
Poids de la formule 532.56
Pourcentage de pureté >98%
missing translation for 'provideContentCorrection'

missing translation for 'productTitle'

missing translation for 'byClickingSubmit' missing translation for 'privacyPolicy'.