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SMN Mouse, Unlabeled, Clone: 8, BD
Mouse Monoclonal Antibody
Marque: BD Biosciences 610647
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Description
SMN (survival motor neuron) was discovered as a candidate gene, located in chromosome 5q13, for the fatal autosomal Spinal muscular atrophy (SMA) disorder. The SMN gene was missing or interrupted in a significant number of patients with SMA. The SMN protein is 294 amino acids and migrates with apparent molecular weight of 40kDa. In addition to the cytoplasm, other studies localized SMN in dots of 0.1-1.0μm within the nucleus. These novel nuclear structures were named “gems” and found associated to coiled bodies. It was also found that SMN interacts with the RGG box of hnRNP U and fibrillarin. Therefore, the biochemical function of SMN may be in the regulation of mRNA metabolism.
Immunofluorescence, Immunohistochemistry, Western Blotting
Spécification
| SMN | |
| Monoclonal | |
| 250μg/mL | |
| Survival Motor Neuron | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
| Western Blot | |
| 8 | |
| Unconjugated | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| 150 μg | |
| Cell Biology | |
| Canine, Human, Mouse, Rat | |
| IgG1 |
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Nom du produit
For Research Use Only.
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