STEMCELL Technologies 3-Deazaneplanocin A

Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase

Marque: STEMCELL Technologies 72324

Code produit. 17180052

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Description

Deazaneplanocin A (DZNep) is an inhibitor of lysine methyltransferases, particularly EZH2
DZNep therefore acts as an epigenetic modifier, specifically inhibiting the trimethylation of Histone 3, Lysine 27, by depleting levels of EZH2
(Miranda et al.), Tan et al.), Tseng et al.)
Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, VaL^proic Acid, Tranylcypromine, and E-616452, by increasing OCT4 expression at later stages of reprogramming (Hou et al.)
Reactivation of XIST-dependent inactive X chromosomes in human embryonic stem cells (Diaz Perez et al.)
Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.)
Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.)

Spécification

Synonyme	DZNep; NSC 617989
Formule moléculaire	C₁₂H₁₄N₄O₃

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