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2-Deoxy-D-glucose, Tocris Bioscience™
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Quantité:
50 mg
Description
2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.
Spécification
Spécification
| Nom chimique ou matériau | 2-Deoxy-D-glucose |
| CAS | 154-17-6 |
| Formule moléculaire | C6H12O5 |
| Numéro MDL | MFCD00151328 |
| Quantité | 50 mg |
| Synonyme | deoxyglucose, 2-deoxy-d-mannose, 2-deoxy-d-arabinohexose, unii-9g2mp84a8w, d-arabino-hexose, 2-deoxy, arabino-hexose, 2-deoxy, d-glucose, 2-deoxy, 3r,4s,5r-3,4,5,6-tetrahydroxyhexanal, 2 deoxyglucose, 2 deoxy d glucose |
| Clé InChI | PMMURAAUARKVCB-PHUJZJCSNA-N |
| SMILES | OC[C@H]1OC(O)C[C@@H](O)[C@@H]1O |
| Nom IUPAC | (4R,5S,6R)-6-(hydroxymethyl)oxane-2,4,5-triol |
| Poids moléculaire (g/mol) | 164.16 |
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